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To support analyses of genes/proteins related to aging and age-related disorders. To clarify the mechanisms of degenerative changes with age in the functions of nerve synapses (Note 1) through analysis of genes/proteins involved in synaptic function. |
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Established a support system for gene/protein analysis with high-accuracy mass spectrometers. |
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Perform analyses of proteins in human cerebrospinal fluid and urine samples using a technique called disease proteomics (Note 2) to search for biomarkers used to diagnose disorders such as AlzheimerΥs disease, and gene mutations.
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Discovered an important enzyme controlling the plasticity (Note 3) and synaptic functions. Currently conducting further analysis to develop drugs with new mechanisms of action to promote the functions of synapses.
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| Note1F |
A site on a neuron where the neuron connects with and transmits information to another neuron. |
| Note2F |
A technique in which all proteins expressing in a specific cell or tissue are identified in a systematic, comprehensive manner.
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| Note3F |
A property of synapses that continuously changes their transmission efficiency depending on their status of use, considered to be the base for learning and memory.
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